组蛋白分类
组蛋白是真核生物染色体的基本结构蛋白，富含带正电荷的碱性氨基酸（赖氨酸和精氨酸），能与酸性的DNA紧密结合，负责DNA的包装和基因表达的调控。
一.按功能和结构分为两大类
1. 核心组蛋白
| 类型 | 分子量 | 结构特征 | 功能 |
|---|---|---|---|
| H2A | ~14 kDa | 含C端延伸 | 与H2B形成二聚体，稳定核小体结构 |
| H2B | ~14 kDa | 高度保守 | 参与DNA缠绕（约147 bp） |
| H3 | ~17 kDa | 含组蛋白折叠域 | 与H4形成四聚体，构成核小体核心 |
| H4 | ~11 kDa | 最保守的组蛋白 | 参与组蛋白八聚体组装 |
| 靶标 | 产品货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| Histone H2A相关抗体： | ||||
| Histone H2A | APRab12055 | Histone H2A Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Histone H2A | AMRe21481 | Histone H2A Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag |
| Histone H2B相关抗体： | ||||
| Histone H2B | AMRe21413 | Histone H2B Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag |
| Histone H2B | APRab12063 | Histone H2B Rabbit Polyclonal Antibody | Human,Mouse,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H2B | AMM03592 | Histone H2B (7E2) Mouse Monoclonal Antibody | Human,Mouse,Rat | WB,IHC |
| Histone H2B | AMM86158 | Histone H2B Mouse Monoclonal Antibody | Human,Mouse,Rat | WB,ICC |
| Histone H3相关抗体： | ||||
| Histone H3 | AMRe83882 | Histone H3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC |
| Histone H3 | AMM03599 | Histone H3 (Zebrafish Specific) (2C4) Mouse Monoclonal Antibody | Human,Mouse,Rat,Zebrafish | WB |
| Histone H3 | AMRe21336 | Histone H3 Rabbit Monoclonal Antibody | Human,Mouse,Rat,Cat | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag |
| Histone H4相关抗体： | ||||
| Histone H4 | APRab03394 | Histone H4 Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H4 | AMRe21614 | Histone H4 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag |
2. 连接组蛋白
| 类型 | 分子量 | 结构特征 | 功能 |
|---|---|---|---|
| H1 | ~20-22 kDa | 球状结构域+柔性C端尾巴 | 结合核小体进出口DNA（约20 bp），促进30 nm染色质纤维折叠及高级结构形成 |
| 靶标 | 产品货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| Histone H1 | APRab00543 | Histone H1 Rabbit Polyclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,ELISA |
二．组蛋白变体
1. H2A变体家族
| 变体名称 | 表达模式 | 定位/功能 |
|---|---|---|
| H2A.X | 组成型表达 | 全基因组分布；DNA损伤时C端SQE基序磷酸化（γ-H2AX），招募修复因子 |
| H2A.Z | 组成型表达 | 转录启动子、增强子、异染色质边界，促进转录激活与抑制双重功能 |
| macroH2A | 组织特异性 | 雌性哺乳动物失活X染色体（Barr小体）；抑制转录 |
| H2A.Bbd | 睾丸特异 | 转录活跃染色质；降低核小体稳定性 |
| 靶标 | 产品货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| Histone H2A.X | AMRe12056 | Histone H2A.X (13P7) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP |
| Histone H2A.Z | APRab12060 | Histone H2A.Z Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Histone H2A.Z | AMRe12059 | Histone H2A.Z (17I8) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC |
| MACROH2A2 | AMM83434 | MACROH2A2 Mouse Monoclonal Antibody | Human | IHC |
| macroH2A.1 | AMRe13549 | macroH2A.1 (2T18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
2. H3变体家族
| 变体名称 | 表达模式 | 定位/功能 |
|---|---|---|
| H3.1 | RD型，CAF-1复合体介导 | 复制偶联的染色质组装 |
| H3.2 | RD型 | 功能类似H3.1，表达略不同 |
| H3.3 | RI型，HIRA/ATRX/DAXX介导 | 转录活跃区、端粒、着丝粒；与H3.1仅4-5个氨基酸差异但功能迥异 |
| CENP-A | RI型，HJURP介导 | 着丝粒身份决定因子；替代H3形成特殊核小体，招募动粒蛋白 |
| 靶标 | 恩玑货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| Histone H3.3 | APRab12071 | Histone H3.3 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Histone H3.3 | APRab00058 | Histone H3.3 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Histone H3.3 | AMRe85655 | Histone H3.3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC |
3. H1变体家族
| 变体名称 | 表达模式 | 定位/功能 |
|---|---|---|
| H1.0 | 终末分化细胞富集 | 促进染色质高度凝聚 |
| H1.1-H1.5 | 体细胞表达 | 维持染色质基本结构 |
| H1t | 睾丸特异 | 精子发生期染色质重塑 |
| H1oo | 卵母细胞特异 | 早期胚胎发育 |
| 靶标 | 恩玑货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| Histone H1.0 | AMRe12052 | Histone H1.0 (10F13) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Histone H1.2 | AMRe02083 | Histone H1.2 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Histone H1.3 | AMRe02084 | Histone H1.3 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Phospho-HistoneH1.4(T17) | AMRe83776 | Phospho-HistoneH1.4(T17) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC |
三．按表观修饰分类
| 修饰类型 | 示例 |
|---|---|
| 单甲基化（Mono Methyl）：me1 | H3K4me1 |
| 二甲基化（Di Methyl）：me2 | H3K4me2 |
| 三甲基化（Tri Methyl）：me3 | H3K4me3 |
| 乙酰化（Ac） | H3K9ac, H3K27ac, H4K16ac |
| 磷酸化（p） | H3S10ph |
| 泛素化（Ub） | H2AK119ub |
| 其他修饰 | 瓜氨酸化, 乳酸化, 巴豆酰化 |
| 靶标 | 产品货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| 单甲基化修饰相关抗体： | ||||
| Histone H2A(mono methyl K118) | AMRe84153 | Histone H2A(mono methyl K118) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC |
| Histone H2B(mono methylK116) | AMRe84635 | Histone H2B(mono methylK116) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC |
| Mono Methyl-Histone H2B (Arg79) | AMRe04022 | Mono Methyl-Histone H2B (Arg79) Rabbit Monoclonal Antibody | Human | WB |
| Histone H3 (Mono Methyl Lys37) | APRab06135 | Histone H3 (Mono Methyl Lys37) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Histone H3 (Mono Methyl Lys5) | APRab06136 | Histone H3 (Mono Methyl Lys5) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Histone H3(mono methyl K14) | AMRe84518 | Histone H3(mono methyl K14) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC,FC |
| Mono Methyl-Histone H3 (Lys18) | AMRe03281 | Mono Methyl-Histone H3 (Lys18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| Histone H3 (Mono Methyl Lys10) | APRab06134 | Histone H3 (Mono Methyl Lys10) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Histone H3 (Mono Methyl Lys80) | APRab06137 | Histone H3 (Mono Methyl Lys80) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Mono Methyl-Histone H3 (Arg2) | AMRe04012 | Mono Methyl-Histone H3 (Arg2) Rabbit Monoclonal Antibody | Human, Mouse | WB,ICC/IF |
| Mono Methyl-Histone H3 (Lys36) | AMRe03954 | Mono Methyl-Histone H3 (Lys36) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,ICC/IF |
| Mono Methyl-Histone H3 (Lys9) | AMRe03910 | Mono Methyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,ICC/IF |
| Histone H3 (Mono Methyl Lys4) | AMRe21105 | Histone H3 (Mono Methyl Lys4) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| Mono Methyl-Histone H4 (Lys20) | AMRe03937 | Mono Methyl-Histone H4 (Lys20) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,ICC/IF |
| Mono/Di/TriMethyl-Histone H3 (Lys79) | AMRe03999 | Mono/Di/TriMethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC |
| 二甲基化修饰相关抗体： | ||||
| DiMethyl-Histone H3 (Lys27) | AMM03581 | DiMethyl-Histone H3 (Lys27) (5F6) Mouse Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,IP |
| Histone H3 (Di Methyl Lys10) | APRab06125 | Histone H3 (Di Methyl Lys10) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Histone H3 (Di Methyl Lys5) | APRab06130 | Histone H3 (Di Methyl Lys5) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| DiMethyl-Histone H3 (Lys4) | APRab00675 | DiMethyl-Histone H3 (Lys4) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP,ChIP |
| Histone H3 (Di-Methyl-K80) | APRab06133 | Histone H3 (Di-Methyl-K80) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
| DiMethyl-Histone H3 (Lys36) | AMRe03906 | DiMethyl-Histone H3 (Lys36) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,ICC/IF |
| DiMethyl-Histone H3 (Lys79) | AMRe03979 | DiMethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,ICC/IF |
| Histone H3 (Di Methyl Lys9) | AMRe21084 | Histone H3 (Di Methyl Lys9) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| 三甲基化修饰相关抗体： | ||||
| Histone H3(Tri Methyl Lys79) | AMM06155 | Histone H3(Tri Methyl Lys79)(3G3)Mouse Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,IP |
| Histone H3 (Tri Methyl Lys4) | AMRe21106 | Histone H3 (Tri Methyl Lys4) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| Histone H3(Tri Methyl Lys36) | AMM06152 | Histone H3(Tri Methyl Lys36)(Q12)Mouse Monoclonal Antibody | Human,Mouse,Rat | WB |
| Histone H3 (Tri-Methyl-K5) | APRab06144 | Histone H3 (Tri-Methyl-K5) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Tri-Methyl-Histone H3 (K10) | APRab04156 | Tri-Methyl-Histone H3 (K10) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,ELISA |
| Tri Methyl-Histone H3 (Lys14) | APRab00850 | Tri Methyl-Histone H3 (Lys14) Rabbit Polyclonal Antibody | Human,Rat | WB |
| Histone H3 (Tri Methyl Lys27) | AMRe21116 | Histone H3 (Tri Methyl Lys27) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| Tri Methyl-Histone H3 (Lys9) | AMRe87560 | Tri Methyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| 乙酰化修饰相关抗体： | ||||
| Histone H4 (Acetyl Lys16) | APRab06213 | Histone H4 (Acetyl Lys16) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Histone H4 (Acetyl Lys12) | APRab06212 | Histone H4 (Acetyl Lys12) Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H4 (Acetyl Lys5) | APRab06215 | Histone H4 (Acetyl Lys5) Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H2B (Acetyl Lys15) | APRab06196 | Histone H2B (Acetyl Lys15) Rabbit Polyclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,ELISA |
| Histone H4 (Acetyl Lys8) | APRab06216 | Histone H4 (Acetyl Lys8) Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H3 (Acetyl Lys27) | APRab06206 | Histone H3 (Acetyl Lys27) Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey,Arabidopsis thaliana | WB,IHC,ICC/IF,ELISA,IP |
| Acetyl-Histone H4 (Lys5) | AMRe03268 | Acetyl-Histone H4 (Lys5) Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,IP |
| Histone H2B (Acetyl Lys126) | APRab06195 | Histone H2B (Acetyl Lys126) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Acetyl-Histone H3 (Lys4) | AMRe03275 | Acetyl-Histone H3 (Lys4) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC/IF |
| Acetyl-HistoneH3(LYs9) | AMRe84307 | Acetyl-HistoneH3(LYs9) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC,IP |
| Acetyl-Histone H3(Lys18) | AMRe84527 | Acetyl-Histone H3(Lys18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC,IP |
| Acetyl-Histone H3(Lys23) | AMRe84536 | Acetyl-Histone H3(Lys23) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC,IP |
| Acetyl Histone H1 (K25) | APRab04160 | Acetyl Histone H1 (K25) Rabbit Polyclonal Antibody | Human,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H3 (Acetyl Lys14) | APRab06202 | Histone H3 (Acetyl Lys14) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,ELISA |
| Histone H3 (Acetyl Lys123) | APRab06200 | Histone H3 (Acetyl Lys123) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Acetyl-Histone H2B (Lys20) | APRab00701 | Acetyl-Histone H2B (Lys20) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP,ChIP |
| Histone H2B (Acetyl Lys21) | APRab06197 | Histone H2B (Acetyl Lys21) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,ELISA |
| Histone H2B (Acetyl-Lys24/25) | APRab06199 | Histone H2B (Acetyl-Lys24/25) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,ELISA |
| Acetyl-Histone H4 (Lys16) | APRab00849 | Acetyl-Histone H4 (Lys16) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| 磷酸化修饰相关抗体： | ||||
| Phospho-Histone H3 (Ser10/Thr11) | AMRe03296 | Phospho-Histone H3 (Ser10/Thr11) Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,IP |
| Phospho-HistoneH3(S10) | AMRe83712 | Phospho-HistoneH3(S10) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,IP |
| Phospho-Histone H2A.X (Ser139) | AMM03680 | Phospho-Histone H2A.X (Ser139) (7G9) Mouse Monoclonal Antibody | Human,Mouse | WB,ICC/IF |
| Phospho-Histone H3 (Ser28) | AMRe02090 | Phospho-Histone H3 (Ser28) Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC,ICC/IF |
| Phospho-HistoneH1.4(T17) | AMRe83776 | Phospho-HistoneH1.4(T17) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC |
| Phospho-Histone H2A.X (Ser139) | AMRe03773 | Phospho-Histone H2A.X (Ser139) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| Phospho-Histone H3 (Thr3) | AMRe03284 | Phospho-Histone H3 (Thr3) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF |
| Phospho-Histone H2A (Ser129) | APRab00687 | Phospho-Histone H2A (Ser129) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
| Phospho-Histone H4 (Ser1) | APRab00852 | Phospho-Histone H4 (Ser1) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC |
| Phospho-HistoneH2B(T129) | AMRe83770 | Phospho-HistoneH2B(T129) Rabbit Monoclonal Antibody | Yeast | WB |
| Histone H3 (Phospho Thr3) | AMRe21090 | Histone H3 (Phospho Thr3) Rabbit Monoclonal Antibody | Human | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag |
| 其他修饰相关抗体： | ||||
| Histone deacetylase 9 | APRab12050 | Histone deacetylase 9 Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,IHC,ICC/IF,ELISA |
| Histone deacetylase 7a | APRab12049 | Histone deacetylase 7a Rabbit Polyclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,ELISA |
| Histone deacetylase 6 | APRab12048 | Histone deacetylase 6 Rabbit Polyclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,ELISA |
| Histone deacetylase 10 | APRab12047 | Histone deacetylase 10 Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Histone H2B(crotonylK12) | AMRe84162 | Histone H2B(crotonylK12) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC |
| Histone H2B(formyl K116) | AMRe84155 | Histone H2B(formyl K116) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC |
| Histone H2B(formyl K108) | AMRe84632 | Histone H2B(formyl K108) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC |
| Histone H3(symmetricdimethylR17) | AMRe84144 | Histone H3(symmetricdimethylR17) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC |
| Crotonyl-Histone H2B (Lys12) | AMRe03903 | Crotonyl-Histone H2B (Lys12) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Crotonyl-Histone H2B (Lys12) | AMRe87546 | Crotonyl-Histone H2B (Lys12) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| Formyl-Histone H3 | AMRe86229 | Formyl-Histone H3 (Lys122) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC |
| Histone H3(formylK122) | AMRe84637 | Histone H3(formylK122) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC |
| Histone H3(mutated K27Met) | AMRe84538 | Histone H3(mutated K27Met) Rabbit Monoclonal Antibody | Human | WB,ICC,IP |
| Histone H3 (Citrulline R2+R8+R17) | APRab00455 | Histone H3 (Citrulline R2+R8+R17) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
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