研究领域介绍

Cadherin-Catenin The tumor microenvironment (TME) has been shown to play an important role in tumor initiation, development, and metastasis. Numerous factors contribute to the nature of the TME such as the presence of immune cells; T-cells, B-cells, and natural killer (NK) cells, and wider environmental factors, such as extracellular matrix (ECM) stiffness, hypoxia, and interstitial pressure. Amongst all these various factors, fibroblasts have been suggested to play a key role in tumor development.

ER stress-induced autophagy is the core mechanism by which cells respond to protein homeostasis imbalances.

Chaperone-mediated autophagy (CMA) is a process triggering the lysosomal-mediated degradation of specific protein targets. CMA is induced by a variety of stresses, including starvation, genotoxic insults, oxidative stress, and hypoxia.

ATM (Ataxia Telangiectasia Mutated) is a serine/threonine protein kinase best known for its role in the DNA damage signaling cascade in response to DNA double-strand breaks (DSBs).

Autophagosome markers are molecular tools used to identify, localize autophagosomes and evaluate autophagic activity, serving as core components in studying autophagic mechanisms and analyzing autophagic abnormalities related to diseases.

ATP-dependent chromatin remodeling complexes play an essential role in the regulation of various nuclear processes, such as gene expression, DNA replication, and repair. The SWI/SNF chromatin remodeling complex consists of more than 10 subunits with a single molecule of the ATPase catalytic subunit BRM or BRG1, but not both. The activities of these two subunits drive the disruption of histone-DNA contacts that lead to changes in accessibility of crucial regulatory elements within chromatin.

Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure.

α-thalassemia/mental retardation X-linked (ATRX) is a transcriptional regulator and helicase that belongs to the SNF2 family of chromatin remodeling proteins. Together with its binding partner death-associated protein 6 (Daxx), ATRX acts as histone chaperone to deposit histone variant H3.3 at repetitive DNA sequences such as telomeric, pericentric, and ribosomal gene repeats.

Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress.

Astrocytes are the most prevalent type of glial cell in the CNS and are found within the brain and spinal cord. In a healthy nervous system, astrocytes play essential roles in development, regulation of blood flow (by supporting endothelial cells in the blood brain barrier), synaptic transmission and function, and energy and metabolism (by providing nutrients to neurons and synthesizing certain neurotransmitters). The loss or abnormal function of astrocytes is implicated in a wide variety of neurodegenerative disease processes. Chronic activation of astrocytes results in the formation of lesions similar to those observed in Alzheimer’s Disease and Huntington’s Disease. Some useful astrocyte markers include GFAP and ALDH1L1.